The Hair Growth Cycle
No matter the cause or type of hair loss, hair thinning or hair growth disorder the Hair Growth Cycle is always negatively affected.
Therefore, being aware of the different stages and progression of the Hair Growth Cycle is crucial for successfully approaching any hair growth disorder.
The Normal Hair Growth Cycle
Described simply, the Hair Growth Cycle has three phases.
Growth Phase
Transition Phase
Resting Phase
Follicular Proteoglycans’ Role During the Normal Hair Growth Cycle
During normal Hair Growth Cycle, there are optimal thresholds at which specific proteoglycans exert their modulatory effect to ensure that balanced and normal healthy regulated cycling takes place in a timely fashion.
Normal Hair Growth Cycle
The Disrupted Hair Growth Cycle
Regardless of the hair loss cause, the Hair Growth Cycle is always negatively affected. This results in a disrupted Hair Growth Cycle. Often the following consequences occur:
Reduced Growth Phase
Early Transition Phase
Prolonged Resting Phase
Follicular Proteoglycan Imbalance Contributes to Disrupting the Hair Growth Cycle
When the concentration of specific follicular proteoglycans is below a specific threshold, their reduced presence prevents the activation and modulation of the complex process of hair follicle growth. This unbalances normal healthy regulated Hair Growth Cycle. An extended period of dysregulation and a continuous ‘lower than normal’ concentration of proteoglycans causes follicular degradation – this is known as Proteoglycan Follicular Atrophy.
Proteoglycan Follicular Atrophy follows on from a period of Follicular Hypo-Glycania during which the specific follicular proteoglycans needed for normal healthy hair growth waste away; this prevents the activation and regulation of the complex process of hair follicle growth in stages.
Proteoglycan Follicular Atrophy
Proteoglycan Replacement Therapy is the only clinically proven method to address Proteoglycan Follicular Atrophy.
Normalising the Hair Growth Cycle
The goal of any treatment approach for hair loss and/or hair growth disruptions in women and men, no matter the cause and type, is to use a baseline approach that normalises and restores this disruption to a normal, healthy Hair Growth Cycle and replenishes the proteoglycans which have wasted away due to atrophy – without compromising safety and ease of use.
Normalising the Hair Growth Cycle
Proteoglycan Replacement Therapy Works Actively with the Hair Growth Cycle
As Proteoglycan Follicular Atrophy is the underlying aetiology for a disrupted Hair Growth Cycle and follicular miniaturisation, the pharmacologic enhancement of key proteoglycans’ content, and synthesis in and around the follicle, presents an attainable therapeutic target in treating both Female Pattern Hair Loss and Telogen Effluvium.
One available and safe method of increasing the concentration of specific hair follicle proteoglycans and normalising the Hair Growth Cycle is to orally administer bioavailable proteoglycans, referred to as Proteoglycan Replacement Therapy.
This targeted approach to addressing Proteoglycan Follicular Atrophy counteracts any negative imbalance to the Hair Growth Cycle induced by Follicular Hypo-Glycania and has proven to be effective in treating female and male hair loss globally.
Proteoglycan Replacement Therapy is widely used as a monotherapy or as part of any multitherapy approach.
Effect of Proteoglycan Replacement Therapy